Coadministration of Atazanavir-Ritonavir and Zinc Sulfate: Impact on Hyperbilirubinemia and Pharmacokinetics

Atazanavir (ATV) causes an elevation of unconjugated hyperbilirubinemia (HBR) as a result of UDP glucuronyltransferase (UGT) 1A1 inhibition. Zinc sulfate (ZnSO(4)) reduces unconjugated hyperbilirubinemia in individuals with Gilbert's syndrome. We assessed the changes in total, conjugated, and u...

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Main Authors: Moyle, Graeme, Else, Laura, Jackson, Akil, Back, David, Yapa, Manisha H., Seymour, Natalia, Ringner-Nackter, Lisa, Karolia, Zeenat, Gazzard, Brian, Boffito, Marta
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719779/
https://ncbi.nlm.nih.gov/pubmed/23689708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00357-13
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