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Evaluation of universal versus genotype-guided efavirenz dose reduction in pregnant women using population pharmacokinetic modeling

OBJECTIVES: Lack of data on the pharmacokinetics of efavirenz in pregnant women at the 400 mg reduced dose currently prevents universal roll out. Population pharmacokinetic modeling was used to explore pharmacokinetic end-points at 200, 400, and 600 mg daily doses in pregnant women stratified by CYP...

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Bibliografske podrobnosti
izdano v:J Antimicrob Chemother
Main Authors: Olagunju, Adeniyi, Schipani, Alessandro, Bolaji, Oluseye, Khoo, Saye, Owen, Andrew
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614711/
https://ncbi.nlm.nih.gov/pubmed/29029267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx334
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