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Evaluation of universal versus genotype-guided efavirenz dose reduction in pregnant women using population pharmacokinetic modeling

OBJECTIVES: Lack of data on the pharmacokinetics of efavirenz in pregnant women at the 400 mg reduced dose currently prevents universal roll out. Population pharmacokinetic modeling was used to explore pharmacokinetic end-points at 200, 400, and 600 mg daily doses in pregnant women stratified by CYP...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Antimicrob Chemother
Prif Awduron: Olagunju, Adeniyi, Schipani, Alessandro, Bolaji, Oluseye, Khoo, Saye, Owen, Andrew
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614711/
https://ncbi.nlm.nih.gov/pubmed/29029267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx334
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