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Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1

Cyclins E1 drives the initiation of DNA replication, and deregulation of its periodic expression leads to mitotic delay associated with genomic instability. Since it is not known whether the closely related protein cyclin E2 shares these properties, we overexpressed cyclin E2 in breast cancer cells....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Caldon, C. Elizabeth, Sergio, C. Marcelo, Burgess, Andrew, Deans, Andrew J., Sutherland, Robert L., Musgrove, Elizabeth A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594261/
https://ncbi.nlm.nih.gov/pubmed/23324395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23512
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