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Differences in degradation lead to asynchronous expression of cyclin E1 and cyclin E2 in cancer cells
Cyclin E1 is expressed at the G₁/S phase transition of the cell cycle to drive the initiation of DNA replication and is degraded during S/G₂M. Deregulation of its periodic degradation is observed in cancer and is associated with increased proliferation and genomic instability. We identify that in ca...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594260/ https://ncbi.nlm.nih.gov/pubmed/23324394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23409 |
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