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Estrogen Regulation of Cyclin E2 Requires Cyclin D1 but Not c-Myc

During estrogen-induced proliferation, c-Myc and cyclin D1 initiate independent pathways that activate cyclin E1-Cdk2 by sequestration and/or downregulation of the CDK inhibitor p21(Waf1/Cip1), without significant increases in cyclin E1 protein levels. In contrast, cyclin E2 undergoes a marked incre...

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Détails bibliographiques
Auteurs principaux: Caldon, C. Elizabeth, Sergio, C. Marcelo, Schütte, Judith, Boersma, Marijke N., Sutherland, Robert L., Carroll, Jason S., Musgrove, Elizabeth A.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725719/
https://ncbi.nlm.nih.gov/pubmed/19564413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00269-09
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