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Estrogen Regulation of Cyclin E2 Requires Cyclin D1 but Not c-Myc
During estrogen-induced proliferation, c-Myc and cyclin D1 initiate independent pathways that activate cyclin E1-Cdk2 by sequestration and/or downregulation of the CDK inhibitor p21(Waf1/Cip1), without significant increases in cyclin E1 protein levels. In contrast, cyclin E2 undergoes a marked incre...
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Auteurs principaux: | , , , , , , |
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Format: | Artigo |
Langue: | Inglês |
Publié: |
American Society for Microbiology (ASM)
2009
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2725719/ https://ncbi.nlm.nih.gov/pubmed/19564413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00269-09 |
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