Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

Parkinson disease and dementia with Lewy bodies are featured with the formation of Lewy bodies composed mostly of α-synuclein (α-Syn) in the brain. Although evidence indicates that the large oligomeric or protofibril forms of α-Syn are neurotoxic agents, the detailed mechanisms of the toxic function...

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Detaylı Bibliyografya
Asıl Yazarlar: Choi, Bong-Kyu, Choi, Mal-Gi, Kim, Jae-Yeol, Yang, Yoosoo, Lai, Ying, Kweon, Dae-Hyuk, Lee, Nam Ki, Shin, Yeon-Kyun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2013
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593925/
https://ncbi.nlm.nih.gov/pubmed/23431141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218424110
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