eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition

Recognition of the methyl-7-guanosine (m(7)G) cap structure on mRNA is an essential feature of mRNA metabolism and thus gene expression. Eukaryotic translation initiation factor 4E (eIF4E) promotes translation, mRNA export, proliferation, and oncogenic transformation dependent on this cap-binding ac...

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Bibliographic Details
Main Authors: Osborne, Michael J., Volpon, Laurent, Kornblatt, Jack A., Culjkovic-Kraljacic, Biljana, Baguet, Aurélie, Borden, Katherine L. B.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593863/
https://ncbi.nlm.nih.gov/pubmed/23431134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216862110
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