Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics

CO(2) is produced abundantly by cardiac mitochondria. Thus an efficient means for its venting is required to support metabolism. Carbonic anhydrase (CA) enzymes, expressed at various sites in ventricular myocytes, may affect mitochondrial CO(2) clearance by catalyzing CO(2) hydration (to H(+) and HC...

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Bibliografiske detaljer
Main Authors: Schroeder, Marie A., Ali, Mohammad A., Hulikova, Alzbeta, Supuran, Claudiu T., Clarke, Kieran, Vaughan-Jones, Richard D., Tyler, Damian J., Swietach, Pawel
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593844/
https://ncbi.nlm.nih.gov/pubmed/23431149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213471110
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