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Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics

CO(2) is produced abundantly by cardiac mitochondria. Thus an efficient means for its venting is required to support metabolism. Carbonic anhydrase (CA) enzymes, expressed at various sites in ventricular myocytes, may affect mitochondrial CO(2) clearance by catalyzing CO(2) hydration (to H(+) and HC...

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Detalhes bibliográficos
Main Authors: Schroeder, Marie A., Ali, Mohammad A., Hulikova, Alzbeta, Supuran, Claudiu T., Clarke, Kieran, Vaughan-Jones, Richard D., Tyler, Damian J., Swietach, Pawel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593844/
https://ncbi.nlm.nih.gov/pubmed/23431149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213471110
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