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A bi-directional, iterative approach to the structural delineation of the functional “chemoprint” in GPR40 for agonist recognition
GPR40, free fatty acid receptor 1 (FFAR1), is a member of the GPCR superfamily and a possible target for the treatment of type 2 diabetes. In this work we conducted a bi-directional iterative investigation, including computational modeling and site-directed mutagenesis, aimed at delineating amino ac...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3592210/ https://ncbi.nlm.nih.gov/pubmed/17552505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0614782 |
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