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Discovery of novel agonists and antagonists of the free fatty acid receptor one (FFAR1) using virtual screening
The G protein-coupled receptor free fatty acid receptor 1 (FFAR1), previously named GPR40, is a possible novel target for the treatment of type 2 diabetes. In an attempt to identify new ligands for this receptor, we performed virtual screening (VS) based on 2D-similarity, 3D-pharmacophore searches a...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711565/ https://ncbi.nlm.nih.gov/pubmed/18193825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm7012425 |
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