Protection Afforded by an HIV Vaccine Candidate in Macaques Depends on the Dose of SIV(mac251) at Challenge Exposure

We used the simian immunodeficiency virus mac251 (SIV(mac251)) macaque model to study the effect of the dose of mucosal exposure on vaccine efficacy. We immunized macaques with a DNA prime followed by SIV gp120 protein immunization with ALVAC-SIV and gp120 in alum, and we challenged them with SIV(ma...

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Главные авторы: Vaccari, Monica, Keele, Brandon F., Bosinger, Steven E., Doster, Melvin N., Ma, Zhong-Min, Pollara, Justin, Hryniewicz, Anna, Ferrari, Guido, Guan, Yongjun, Forthal, Donald N., Venzon, David, Fenizia, Claudio, Morgan, Tia, Montefiori, David, Lifson, Jeffrey D., Miller, Chris J., Silvestri, Guido, Rosati, Margherita, Felber, Barbara K., Pavlakis, George N., Tartaglia, James, Franchini, Genoveffa
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2013
Предметы:
Vaccines and Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592147/
https://ncbi.nlm.nih.gov/pubmed/23325681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02863-12
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