Protection Afforded by an HIV Vaccine Candidate in Macaques Depends on the Dose of SIV(mac251) at Challenge Exposure

We used the simian immunodeficiency virus mac251 (SIV(mac251)) macaque model to study the effect of the dose of mucosal exposure on vaccine efficacy. We immunized macaques with a DNA prime followed by SIV gp120 protein immunization with ALVAC-SIV and gp120 in alum, and we challenged them with SIV(ma...

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Main Authors: Vaccari, Monica, Keele, Brandon F., Bosinger, Steven E., Doster, Melvin N., Ma, Zhong-Min, Pollara, Justin, Hryniewicz, Anna, Ferrari, Guido, Guan, Yongjun, Forthal, Donald N., Venzon, David, Fenizia, Claudio, Morgan, Tia, Montefiori, David, Lifson, Jeffrey D., Miller, Chris J., Silvestri, Guido, Rosati, Margherita, Felber, Barbara K., Pavlakis, George N., Tartaglia, James, Franchini, Genoveffa
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2013
נושאים:
Vaccines and Antiviral Agents
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592147/
https://ncbi.nlm.nih.gov/pubmed/23325681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02863-12
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