Protection Afforded by an HIV Vaccine Candidate in Macaques Depends on the Dose of SIV(mac251) at Challenge Exposure

We used the simian immunodeficiency virus mac251 (SIV(mac251)) macaque model to study the effect of the dose of mucosal exposure on vaccine efficacy. We immunized macaques with a DNA prime followed by SIV gp120 protein immunization with ALVAC-SIV and gp120 in alum, and we challenged them with SIV(ma...

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Main Authors: Vaccari, Monica, Keele, Brandon F., Bosinger, Steven E., Doster, Melvin N., Ma, Zhong-Min, Pollara, Justin, Hryniewicz, Anna, Ferrari, Guido, Guan, Yongjun, Forthal, Donald N., Venzon, David, Fenizia, Claudio, Morgan, Tia, Montefiori, David, Lifson, Jeffrey D., Miller, Chris J., Silvestri, Guido, Rosati, Margherita, Felber, Barbara K., Pavlakis, George N., Tartaglia, James, Franchini, Genoveffa
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2013
主題:
Vaccines and Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592147/
https://ncbi.nlm.nih.gov/pubmed/23325681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02863-12
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