Dual-site Interactions of p53 Protein Transactivation Domain with Anti-apoptotic Bcl-2 Family Proteins Reveal a Highly Convergent Mechanism of Divergent p53 Pathways

Molecular interactions between the tumor suppressor p53 and the anti-apoptotic Bcl-2 family proteins play an important role in the transcription-independent apoptosis of p53. The p53 transactivation domain (p53TAD) contains two conserved ΦXXΦΦ motifs (Φ indicates a bulky hydrophobic residue and X is...

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Bibliographic Details
Main Authors: Ha, Ji-Hyang, Shin, Jae-Sun, Yoon, Mi-Kyung, Lee, Min-Sung, He, Fahu, Bae, Kwang-Hee, Yoon, Ho Sup, Lee, Chong-Kil, Park, Sung Goo, Muto, Yutaka, Chi, Seung-Wook
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591646/
https://ncbi.nlm.nih.gov/pubmed/23316052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400754
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