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Apoptotic threshold is lowered by p53 transactivation of caspase-6
Little is known about how a cell's apoptotic threshold is controlled after exposure to chemotherapy, although the p53 tumor suppressor has been implicated. We identified executioner caspase-6 as a transcriptional target of p53. The mechanism involves DNA binding by p53 to the third intron of th...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC123168/ https://ncbi.nlm.nih.gov/pubmed/12089322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.132241599 |
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