Cytoplasmic pro-apoptotic function of the tumor suppressor p73 is mediated through a modified mode of recognition of the anti-apoptotic regulator Bcl-X(L)

In response to genotoxic stress, the tumor suppressor protein p73 induces apoptosis and cell cycle arrest. Despite extensive studies on p73-mediated apoptosis, little is known about the cytoplasmic apoptotic function of p73. Here, using H1299 lung cancer cells and diverse biochemical approaches, inc...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Yoon, Mi-Kyung, Kim, Bu-Yeon, Lee, Ji-Young, Ha, Ji-Hyang, Kim, Sung Ah, Lee, Dong-Hwa, Lee, Min-Sung, Lee, Mi-Kyung, Choi, Jin Sun, Cho, Jin Hwa, Kim, Jeong-Hoon, Kim, Sunhong, Song, Jaewhan, Park, Sung Goo, Park, Byoung Chul, Bae, Kwang-Hee, Choi, Sang Un, Chi, Seung-Wook
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314122/
https://ncbi.nlm.nih.gov/pubmed/30429221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003061
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