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Architecture and Assembly of HIV Integrase Multimers in the Absence of DNA Substrates
We have applied small angle x-ray scattering and protein cross-linking coupled with mass spectrometry to determine the architectures of full-length HIV integrase (IN) dimers in solution. By blocking interactions that stabilize either a core-core domain interface or N-terminal domain intermolecular c...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3591645/ https://ncbi.nlm.nih.gov/pubmed/23322775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.434431 |
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