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Retroviral Integrases Promote Fraying of Viral DNA Ends

In the initial step of integration, retroviral integrase (IN) introduces precise nicks in the degenerate, short inverted repeats at the ends of linear viral DNA. The scissile phosphodiester bond is located immediately 3′ of a highly conserved CA/GT dinucleotide, usually 2 bp from the ends. These nic...

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Detalhes bibliográficos
Main Authors: Katz, Richard A., Merkel, George, Andrake, Mark D., Roder, Heinrich, Skalka, Anna Marie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138259/
https://ncbi.nlm.nih.gov/pubmed/21622554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229179
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