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Retroviral Integrases Promote Fraying of Viral DNA Ends
In the initial step of integration, retroviral integrase (IN) introduces precise nicks in the degenerate, short inverted repeats at the ends of linear viral DNA. The scissile phosphodiester bond is located immediately 3′ of a highly conserved CA/GT dinucleotide, usually 2 bp from the ends. These nic...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3138259/ https://ncbi.nlm.nih.gov/pubmed/21622554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229179 |
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