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Topoisomerase IIβ Deficiency Enhances Camptothecin-induced Apoptosis
Camptothecin (CPT), a topoisomerase (Top) I-targeting drug that stabilizes Top1-DNA covalent adducts, can induce S-phase-specific cytotoxicity due to the arrest of progressing replication forks. However, CPT-induced non-S-phase cytotoxicity is less well characterized. In this study, we have identifi...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3591627/ https://ncbi.nlm.nih.gov/pubmed/23344961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415471 |
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