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Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies
Drugs that target DNA topoisomerase II (Top2), including etoposide (VP-16), doxorubicin, and mitoxantrone, are among the most effective anticancer drugs in clinical use. However, Top2-based chemotherapy has been associated with higher incidences of secondary malignancies, notably the development of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1904155/ https://ncbi.nlm.nih.gov/pubmed/17578914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704002104 |
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