Topoisomerase IIβ Deficiency Enhances Camptothecin-induced Apoptosis

Camptothecin (CPT), a topoisomerase (Top) I-targeting drug that stabilizes Top1-DNA covalent adducts, can induce S-phase-specific cytotoxicity due to the arrest of progressing replication forks. However, CPT-induced non-S-phase cytotoxicity is less well characterized. In this study, we have identifi...

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Autors principals: Lin, Ren-Kuo, Ho, Chia-Wen, Liu, Leroy F., Lyu, Yi Lisa
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591627/
https://ncbi.nlm.nih.gov/pubmed/23344961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.415471
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