A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition

The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies. We immunized llamas with gp41-MPER proteoliposo...

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Huvudupphovsmän: Lutje Hulsik, David, Liu, Ying-ying, Strokappe, Nika M., Battella, Simone, El Khattabi, Mohamed, McCoy, Laura E., Sabin, Charles, Hinz, Andreas, Hock, Miriam, Macheboeuf, Pauline, Bonvin, Alexandre M. J. J., Langedijk, Johannes P. M., Davis, David, Forsman Quigley, Anna, Aasa-Chapman, Marlén M. I., Seaman, Michael S., Ramos, Alejandra, Poignard, Pascal, Favier, Adrien, Simorre, Jean-Pierre, Weiss, Robin A., Verrips, C. Theo, Weissenhorn, Winfried, Rutten, Lucy
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591319/
https://ncbi.nlm.nih.gov/pubmed/23505368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003202
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