Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein

Herpesvirus-associated ubiquitin specific protease (HAUSP) regulates the stability of p53 and MDM2, implicating HAUSP as a therapeutic target for tuning p53-mediated anti-tumor activity. Here, we report the structural analysis of HAUSP with Kaposi’s sarcoma-associated herpesvirus vIRF4 and the disco...

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Detalhes bibliográficos
Main Authors: Lee, Hye-Ra, Choi, Won-Chan, Lee, Stacy, Hwang, Jungwon, Hwang, Eunha, Guchhait, Koushik, Haas, Juergen, Toth, Zsolt, Jeon, Young Ho, Oh, Tae-Kwang, Kim, Myung Hee, Jung, Jae U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589550/
https://ncbi.nlm.nih.gov/pubmed/22056774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2142
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