Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 Targets MDM2 To Deregulate the p53 Tumor Suppressor Pathway

Cells infected by viruses utilize interferon (IFN)-mediated and p53-mediated irreversible cell cycle arrest and apoptosis as part of the overall host surveillance mechanism to ultimately block viral replication and dissemination. Viruses, in turn, have evolved elaborate mechanisms to subvert IFN- an...

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Autors principals: Lee, Hye-Ra, Toth, Zsolt, Shin, Young C., Lee, Jong-Soo, Chang, Heesoon, Gu, Wei, Oh, Tae-Kwang, Kim, Myung Hee, Jung, Jae U.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Cellular Response to Infection
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698538/
https://ncbi.nlm.nih.gov/pubmed/19369353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02353-08
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