Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G(1)-S Cell Cycle Progression via Deregulation of the cyclin D1 Gene

Kaposi's sarcoma-associated herpesvirus (KSHV) infection modulates the host cell cycle to create an environment optimal for its viral-DNA replication during the lytic life cycle. We report here that KSHV vIRF4 targets the β-catenin/CBP cofactor and blocks its occupancy on the cyclin D1 promoter...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Lee, Hye-Ra, Mitra, Jaba, Lee, Stacy, Gao, Shou-Jiang, Oh, Tae-Kwang, Kim, Myung Hee, Ha, Taekjip, Jung, Jae U.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4702683/
https://ncbi.nlm.nih.gov/pubmed/26491150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01897-15
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