TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells

TRIM28 is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process is the protection of cellular gene expression in early embryos from perturbation by cis-acting activators contained within these retroelements...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Rowe, Helen M., Kapopoulou, Adamandia, Corsinotti, Andrea, Fasching, Liana, Macfarlan, Todd S., Tarabay, Yara, Viville, Stéphane, Jakobsson, Johan, Pfaff, Samuel L., Trono, Didier
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Cold Spring Harbor Laboratory Press 2013
विषय:
Research
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589534/
https://ncbi.nlm.nih.gov/pubmed/23233547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.147678.112
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