TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells

TRIM28 is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process is the protection of cellular gene expression in early embryos from perturbation by cis-acting activators contained within these retroelements...

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Autors principals: Rowe, Helen M., Kapopoulou, Adamandia, Corsinotti, Andrea, Fasching, Liana, Macfarlan, Todd S., Tarabay, Yara, Viville, Stéphane, Jakobsson, Johan, Pfaff, Samuel L., Trono, Didier
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589534/
https://ncbi.nlm.nih.gov/pubmed/23233547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.147678.112
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