TRIM28 repression of retrotransposon-based enhancers is necessary to preserve transcriptional dynamics in embryonic stem cells

TRIM28 is critical for the silencing of endogenous retroviruses (ERVs) in embryonic stem (ES) cells. Here, we reveal that an essential impact of this process is the protection of cellular gene expression in early embryos from perturbation by cis-acting activators contained within these retroelements...

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Main Authors: Rowe, Helen M., Kapopoulou, Adamandia, Corsinotti, Andrea, Fasching, Liana, Macfarlan, Todd S., Tarabay, Yara, Viville, Stéphane, Jakobsson, Johan, Pfaff, Samuel L., Trono, Didier
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2013
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589534/
https://ncbi.nlm.nih.gov/pubmed/23233547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.147678.112
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