TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use T...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Fasching, Liana, Kapopoulou, Adamandia, Sachdeva, Rohit, Petri, Rebecca, Jönsson, Marie E., Männe, Christian, Turelli, Priscilla, Jern, Patric, Cammas, Florence, Trono, Didier, Jakobsson, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434221/
https://ncbi.nlm.nih.gov/pubmed/25543143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.12.004
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