The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes

Retrotransposons encompass half of the human genome and contribute to the formation of heterochromatin, which provides nuclear structure and regulates gene expression. Here, we asked if the human silencing hub (HUSH) complex is necessary to silence retrotransposons and whether it collaborates with T...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Robbez-Masson, Luisa, Tie, Christopher H.C., Conde, Lucia, Tunbak, Hale, Husovsky, Connor, Tchasovnikarova, Iva A., Timms, Richard T., Herrero, Javier, Lehner, Paul J., Rowe, Helen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991525/
https://ncbi.nlm.nih.gov/pubmed/29728366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.228171.117
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