LRP6 Enhances Glucose Metabolism by Promoting TCF7L2-dependent Insulin Receptor Expression and IGF Receptor stabilization in Humans

Common genetic variations in Wnt signaling genes have been associated with metabolic syndrome and diabetes by mechanisms that are not well understood. A rare nonconservative mutation in Wnt-coreceptor LRP6 (LRP6(R611C)) has shown to underlie autosomal dominant early onset coronary artery disease, ty...

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Detalhes bibliográficos
Main Authors: Singh, Rajvir, De Aguiar, Renata Belfort, Naik, Sarita, Mani, Sheida, Ostadsharif, Kamal, Wencker, Detlef, Sotoudeh, Masoud, Malekzadeh, Reza, Sherwin, Robert S., Mani, Arya
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589523/
https://ncbi.nlm.nih.gov/pubmed/23395167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.01.009
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