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Mutation in EGFP domain of LRP6 impairs cellular LDL Clearance: Liu. LRP6 and cellular LDL trafficking
Mutation in the EGFP domain of LDL receptor-related protein 6 (LRP6(R611C)) is associated with hypercholesterolemia and early-onset atherosclerosis, but the mechanism by which it causes disease is not known. Cholesterol uptake was examined in cells from LRP6 (+)(/−) mice and LRP6(R611C) mutation car...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3426315/ https://ncbi.nlm.nih.gov/pubmed/18948618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.183863 |
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