Low Density Lipoprotein (LDL) Receptor-related Protein 6 (LRP6) Regulates Body Fat and Glucose Homeostasis by Modulating Nutrient Sensing Pathways and Mitochondrial Energy Expenditure

Body fat, insulin resistance, and type 2 diabetes are often linked together, but the molecular mechanisms that unify their association are poorly understood. Wnt signaling regulates adipogenesis, and its altered activity has been implicated in the pathogenesis of type 2 diabetes and metabolic syndro...

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Main Authors: Liu, Wenzhong, Singh, Rajvir, Choi, Cheol Soo, Lee, Hui-Young, Keramati, Ali R., Samuel, Varman T., Lifton, Richard P., Shulman, Gerald I., Mani, Arya
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293520/
https://ncbi.nlm.nih.gov/pubmed/22232553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.286724
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