Low Density Lipoprotein (LDL) Receptor-related Protein 6 (LRP6) Regulates Body Fat and Glucose Homeostasis by Modulating Nutrient Sensing Pathways and Mitochondrial Energy Expenditure

Body fat, insulin resistance, and type 2 diabetes are often linked together, but the molecular mechanisms that unify their association are poorly understood. Wnt signaling regulates adipogenesis, and its altered activity has been implicated in the pathogenesis of type 2 diabetes and metabolic syndro...

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Autori principali: Liu, Wenzhong, Singh, Rajvir, Choi, Cheol Soo, Lee, Hui-Young, Keramati, Ali R., Samuel, Varman T., Lifton, Richard P., Shulman, Gerald I., Mani, Arya
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293520/
https://ncbi.nlm.nih.gov/pubmed/22232553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.286724
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