LRP6 Protein Regulates Low Density Lipoprotein (LDL) Receptor-mediated LDL Uptake

Genetic variations in LRP6 gene are associated with high serum LDL cholesterol levels. We have previously shown that LDL clearance in peripheral B-lymphocytes of the LRP6(R611C) mutation carriers is significantly impaired. In this study we have examined the role of wild type LRP6 (LRP6(WT)) and LRP6...

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Bibliographic Details
Main Authors: Ye, Zhi-jia, Go, Gwang-Woong, Singh, Rajvir, Liu, Wenzhong, Keramati, Ali Reza, Mani, Arya
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256876/
https://ncbi.nlm.nih.gov/pubmed/22128165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.295287
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