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Impaired LRP6-TCF7L2 activity enhances smooth muscle cell plasticity and causes coronary artery disease
Mutations in Wnt signaling coreceptor LRP6 have been linked to coronary artery disease (CAD) by unknown mechanisms. Here we show that reduced LRP6 activity in LRP6(R611C) mice promotes loss of vascular smooth muscle cell (VSMC) differentiation, leading to aortic medial hyperplasia. Carotid injury au...
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| Publicado en: | Cell Rep |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4626307/ https://ncbi.nlm.nih.gov/pubmed/26489464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.028 |
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