The Combined Hyperlipidemia Caused by Impaired Wnt-LRP6 signaling is reversed by Wnt3a Rescue

The underlying molecular genetic basis of combined hyperlipidemia, the most common atherogenic lipid disorder, is poorly characterized. Rare, non-conservative mutations in the Wnt coreceptor, LRP6, underlie autosomal dominant atherosclerosis, combined hyperlipidemia, and fatty liver disease. Mice wi...

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Bibliografiske detaljer
Main Authors: Go, Gwang-woong, Srivastava, Roshni, Hernandez-Ono, Antonio, Gang, Gyoungok, Smith, Stephen B., Booth, Carmen J., Ginsberg, Henry N., Mani, Arya
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920193/
https://ncbi.nlm.nih.gov/pubmed/24506864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.11.023
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