Impaired LRP6-TCF7L2 activity enhances smooth muscle cell plasticity and causes coronary artery disease

Mutations in Wnt signaling coreceptor LRP6 have been linked to coronary artery disease (CAD) by unknown mechanisms. Here we show that reduced LRP6 activity in LRP6(R611C) mice promotes loss of vascular smooth muscle cell (VSMC) differentiation, leading to aortic medial hyperplasia. Carotid injury au...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Srivastava, Roshni, Go, Gwang-woong, Narayanan, Anand, Zhang, Jiasheng, Mani, Arya
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626307/
https://ncbi.nlm.nih.gov/pubmed/26489464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.09.028
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