LRP6 Enhances Glucose Metabolism by Promoting TCF7L2-dependent Insulin Receptor Expression and IGF Receptor stabilization in Humans

Common genetic variations in Wnt signaling genes have been associated with metabolic syndrome and diabetes by mechanisms that are not well understood. A rare nonconservative mutation in Wnt-coreceptor LRP6 (LRP6(R611C)) has shown to underlie autosomal dominant early onset coronary artery disease, ty...

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Autors principals: Singh, Rajvir, De Aguiar, Renata Belfort, Naik, Sarita, Mani, Sheida, Ostadsharif, Kamal, Wencker, Detlef, Sotoudeh, Masoud, Malekzadeh, Reza, Sherwin, Robert S., Mani, Arya
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589523/
https://ncbi.nlm.nih.gov/pubmed/23395167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.01.009
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