Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion

Caspase-1 is known to activate the proinflammatory cytokines IL-1β and IL-18. Additionally, it can cleave other substrates, including proteins involved in metabolism. Recently, we showed that caspase-1 deficiency in mice strongly reduces high-fat diet-induced weight gain, at least partly caused by a...

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Detalhes bibliográficos
Main Authors: van Diepen, Janna A., Stienstra, Rinke, Vroegrijk, Irene O. C. M., van den Berg, Sjoerd A. A., Salvatori, Daniela, Hooiveld, Guido J., Kersten, Sander, Tack, Cees J., Netea, Mihai G., Smit, Johannes W.A., Joosten, Leo A. B., Havekes, Louis M., van Dijk, Ko Willems, Rensen, Patrick C. N.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3588871/
https://ncbi.nlm.nih.gov/pubmed/23160218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M031963
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