Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion

Caspase-1 is known to activate the proinflammatory cytokines IL-1β and IL-18. Additionally, it can cleave other substrates, including proteins involved in metabolism. Recently, we showed that caspase-1 deficiency in mice strongly reduces high-fat diet-induced weight gain, at least partly caused by a...

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Main Authors: van Diepen, Janna A., Stienstra, Rinke, Vroegrijk, Irene O. C. M., van den Berg, Sjoerd A. A., Salvatori, Daniela, Hooiveld, Guido J., Kersten, Sander, Tack, Cees J., Netea, Mihai G., Smit, Johannes W.A., Joosten, Leo A. B., Havekes, Louis M., van Dijk, Ko Willems, Rensen, Patrick C. N.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2013
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3588871/
https://ncbi.nlm.nih.gov/pubmed/23160218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M031963
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