Role of IRS-1-GRB-2 complexes in insulin signaling.
GRB-2 is a small SH2- and SH3 domain-containing adapter protein that associates with the mammalian SOS homolog to regulate p21ras during growth factor signaling. During insulin stimulation, GRB-2 binds to the phosphorylated Y895VNI motif of IRS-1. Substitution of Tyr-895 with phenylalanine (IRS-1F-8...
Bewaard in:
| Gepubliceerd in: | Mol Cell Biol |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Taylor & Francis
1994
|
| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358725/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8196603/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.6.3577-3587.1994 |
| Tags: |
Geen labels, Wees de eerste die dit record labelt!
|