Role of IRS-1-GRB-2 complexes in insulin signaling.

GRB-2 is a small SH2- and SH3 domain-containing adapter protein that associates with the mammalian SOS homolog to regulate p21ras during growth factor signaling. During insulin stimulation, GRB-2 binds to the phosphorylated Y895VNI motif of IRS-1. Substitution of Tyr-895 with phenylalanine (IRS-1F-8...

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में प्रकाशित:	Mol Cell Biol
मुख्य लेखकों:	Myers, M G, Wang, L M, Sun, X J, Zhang, Y, Yenush, L, Schlessinger, J, Pierce, J H, White, M F
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Taylor & Francis 1994
विषय:	Research Article
ऑनलाइन पहुंच:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC358725/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8196603/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.6.3577-3587.1994
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