Role of IRS-1-GRB-2 complexes in insulin signaling.

GRB-2 is a small SH2- and SH3 domain-containing adapter protein that associates with the mammalian SOS homolog to regulate p21ras during growth factor signaling. During insulin stimulation, GRB-2 binds to the phosphorylated Y895VNI motif of IRS-1. Substitution of Tyr-895 with phenylalanine (IRS-1F-8...

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Bibliographic Details
Main Authors: Myers, M G, Wang, L M, Sun, X J, Zhang, Y, Yenush, L, Schlessinger, J, Pierce, J H, White, M F
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC358725/
https://ncbi.nlm.nih.gov/pubmed/8196603
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