Role of IRS-1-GRB-2 complexes in insulin signaling.

GRB-2 is a small SH2- and SH3 domain-containing adapter protein that associates with the mammalian SOS homolog to regulate p21ras during growth factor signaling. During insulin stimulation, GRB-2 binds to the phosphorylated Y895VNI motif of IRS-1. Substitution of Tyr-895 with phenylalanine (IRS-1F-8...

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Detalhes bibliográficos
Main Authors: Myers, M G, Wang, L M, Sun, X J, Zhang, Y, Yenush, L, Schlessinger, J, Pierce, J H, White, M F
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC358725/
https://ncbi.nlm.nih.gov/pubmed/8196603
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