8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation

The refractoriness of acute promyelocytic leukemia (APL) with t(11;17)(q23;q21) to all-trans retinoic acid (ATRA)-based therapy concerns clinicians and intrigues basic researchers. By using a murine leukemic model carrying both promyelocytic leukemia zinc finger/retinoic acid receptor-α (PLZF/RARα)...

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Dettagli Bibliografici
Autori principali: Jiao, Bo, Ren, Zhi-Hong, Liu, Ping, Chen, Li-Juan, Shi, Jing-Yi, Dong, Ying, Ablain, Julien, Shi, Lin, Gao, Li, Hu, Jun-Pei, Ren, Rui-Bao, de Thé, Hugues, Chen, Zhu, Chen, Sai-Juan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587232/
https://ncbi.nlm.nih.gov/pubmed/23382200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222863110
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