PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.

Recently, we described a recurrent variant translocation, t(11;17)(q23;q21), in acute promyelocytic leukemia (APL) which juxtaposes PLZF, a gene encoding a zinc finger protein, to RARA, encoding retinoic acid receptor alpha (RAR alpha). We have now cloned cDNAs encoding PLZF-RAR alpha chimeric prote...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Chen, Z, Guidez, F, Rousselot, P, Agadir, A, Chen, S J, Wang, Z Y, Degos, L, Zelent, A, Waxman, S, Chomienne, C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521477/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8302850/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.3.1178
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