PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.

Recently, we described a recurrent variant translocation, t(11;17)(q23;q21), in acute promyelocytic leukemia (APL) which juxtaposes PLZF, a gene encoding a zinc finger protein, to RARA, encoding retinoic acid receptor alpha (RAR alpha). We have now cloned cDNAs encoding PLZF-RAR alpha chimeric prote...

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Detalhes bibliográficos
Main Authors: Chen, Z, Guidez, F, Rousselot, P, Agadir, A, Chen, S J, Wang, Z Y, Degos, L, Zelent, A, Waxman, S, Chomienne, C
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC521477/
https://ncbi.nlm.nih.gov/pubmed/8302850
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