RARα-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia

Leukemia-associated chimeric oncoproteins often act as transcriptional repressors, targeting promoters of master genes involved in hematopoiesis. We show that CRABPI (encoding cellular retinoic acid binding protein I) is a target of PLZF, which is fused to RARα by the t(11;17)(q23;q21) translocation...

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Detalhes bibliográficos
Main Authors: Guidez, Fabien, Parks, Sarah, Wong, Henna, Jovanovic, Jelena V., Mays, Ashley, Gilkes, Amanda F., Mills, Kenneth I., Guillemin, Marie-Claude, Hobbs, Robin M., Pandolfi, Pier Paolo, de Thé, Hugues, Solomon, Ellen, Grimwade, David
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2141839/
https://ncbi.nlm.nih.gov/pubmed/18000064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704433104
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