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Targeting the Acute Promyelocytic Leukemia-Associated Fusion Proteins PML/RARα and PLZF/RARα with Interfering Peptides

In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17). For these two translocations, the retinoic acid receptor alpha (RARα) is fused...

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Autori principali: Beez, Sabine, Demmer, Philipp, Puccetti, Elena
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494703/
https://ncbi.nlm.nih.gov/pubmed/23152790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048636
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